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CBG (Cannabigerol): What are the Benefits of this Amazing Active Cannabinoid

Being one of the wells over 120 active cannabinoids that have been identified in the Cannabis plant genus so far, CBG (Cannabigerol)is often referred to as the mother of THC and CBD. Because of this, despite the fact that Cannabigerol is only a minor constituent of the cannabis plant, it is an extremely valuable active cannabinoid, in the absence of which other crucial cannabinoids (including Tetrahydrocannabinol, Cannabidiol, and not the least, Cannabichromene), could not be possibly synthesized.

If you are curious to find more about the potential therapeutic benefits of CBG, as well as more about the science behind this truly amazing active cannabinoid, join us below!

Why is CBG Referred to as “The Mother of Active Cannabinoids”

Cannabis plants do not contain readily-available THC, and neither do they contain readily-available CBD. So, how come is it possible for us to enjoy both THC and/or CBD in different ratios when consuming marijuana through just about any of our favorite methods, such as vaping, topicals, weed tinctures, or munching on cannabis-laced foods, among others

The thing is, cannabis plants produce THCa (tetrahydrocannabinolic acid), and CBDa (Cannabidiolic acid), both of which get converted into the well-known and much-desired THC and CBD after being heated, for instance, when you light up a joint or cook with cannabis. That’s exactly why we need to decarb weed prior to ingesting it for maximum potency since without being introduced to a suitable temperature for a particular period of time, neither THC nor CBD will get activated.

With this in mind, if you ingest raw or simply insufficiently heated up weed, you can take advantage of the acidic forms of THC and CBD (respectively, THCa and CBDa), that are known to possess a whole myriad of potential health benefits. However, the potency of the green medication in terms of psychoactive properties would not be possible to indulge in.

You see, cannabis plants are quite complexly functioning, and nonetheless, sublimely mesmerizing creatures.

When one is trying to learn the basics of the active compounds found in the marijuana plants (active cannabinoids, terpenes, and flavonoids which, by the way, happen to hit more than 400 in number in total!), things can feel very complicated at the start.

But as long as one carries a deep and sincere love for the green medication, getting to know more about the seemingly hard to apprehend, sci-fi-like chemical compounds and processes that take place in the cannabis plant, as well as in one’s body upon consuming the herb, becomes a journey full of excitement. That’s why one of the most intriguing active cannabinoids which still tends to be lesser known than THC and CBD, is nothing less but a pleasure to get better familiar with. Yes, we are talking about CBG (Cannabigerol), aka the mother of active cannabinoids. But what is it that has earned Cannabigerol this astonishing nickname

In order to apprehend CBG’s importance fully, we’d have to go back at a further point in the life of a marijuana plant. In the absence of CBGA, none of the most widely-researched cannabinoids (commonly referred to as “the big six”), in particular, CBD, THC, CBC, THCV, CBN, and nonetheless, CBG, would exist.

Each of these six active cannabinoids starts out as CBGA. What happens next is that they get transformed by enzymes within the very trichomes of the cannabis plant. When this transformation occurs, CBGA synthesizes into CBDA, THCA, CBCA, THCVA (tetrahydrocannabivarin carboxylic acid), and so on. To illustrate this process even better, let’s take, for example, the way THCV is created. At first, CBGVA needs to get broken down to THCVA by the enzyme THCV synthase, so that once heated up, THCVA would turn into THCV.

Back to the raw, acidic forms of active cannabinoids such as THCa and CBDa, Cannabigerol is also not readily available in the cannabis plant, at least not in the form of CBG but instead, it is available in its acidic form: CBGa (Cannabigerolic acid). It is thanks to Cannabigerolic acid (CBGa) how other cannabinoids get synthesized. Being the parent molecule, in the absence of which THCa, CBDa, and CBCa (cannabenzoic acid), among others, could not be possibly synthesized by the cannabis plant, Cannabigerol has earned the well-deserved glory for its unique part in the anatomy, as well as the following effects provided by the active compounds in the marijuana plant, by being nicknamed as the mother of active cannabinoids.

Quintessentially, CBG plays a key role as a chemical precursor to other cannabinoids.

Interestingly, there’s only so much CBGA in a cannabis plant, as when large amounts of it get synthesized into THCA, this leaves a rather smaller amount to be transformed into other cannabinoids (or, respectively, to continue on as CBGA). And that’s exactly why most cannabis strains are high in THC, yet significantly low in other active cannabinoids, such as CBC and CBN.

What’s more, commenting on CBGa being the mother of CBN (Cannabinol) cannabinoid, we should note that CBN is actually the degraded form of THCA, so CBN does not stem directly from CBGa, however, it would be still impossible for THCA to degrade into CBN if it is not thanks to the amazing functions of CBGa.

Ultimately, when speaking of the process that has earned CBG the nickname of “the Mother of All Cannabinoids,” we should keep in mind that it is actually most accurate to state it is CBGA that is “the Mother of All Cannabinoids.”

And to be even more precise and concise, CBGA is best to be referred to as “the Mother of the Big Six Cannabinoids,” but not “the Mother of All Cannabinoids”, since there are well over 100 active cannabinoids that are still very little known because of lack of sufficient research.
Now that we have covered the basics of why CBG is referred to as the mother of active cannabinoids, let’s get down to learning more about what CBG is anyway.

What is Cannabigerol (CBG)

To start with, CBG is a non-intoxicating cannabinoid that is known to play a key role in the cannabis plant biochemistry.

Even though CBG is a non-psychoactive cannabinoid similarly to CBD, these two active cannabinoids bind with completely different receptors in your body’s ECS (endogenous cannabinoid system), therefore, they work in quite different ways, and offer different potential benefits for the consumers.

So, how does CBG interact with CB1 and CB2 receptors CBG is known to act as a possible inhibitor to the psychoactive effects of THC. That’s because,in order for THC to create an intoxicating high, it binds with the brain’s CB1 receptors.

However, CBG has shown to induce the effects of the THC high, thanks to CBG’s unique action on CB1 receptors in the brain that prevents THC from being able to strongly stimulate these receptors. In a nutshell, CBG inhibits the THC high within a certain extent. Since CBG is only present within low levels in the cannabis plant, it doesn’t really get to diminish the effects of THC so detectably, but it does get to induce an intriguing array of effects that are believed to work in perfect synergy with the rest of the active compounds present in the marijuana plant for providing the full spectrum of benefits of medicating with cannabis.

CBG is also said to boost anandamide. Anandamide, known as “the bliss molecule” is an endocannabinoid that increases dopamine levels in one’s body naturally. Anandamide is responsible for the regulation of different crucial health functions such as sleep, appetite, and mood. ()

Not the least, CBG is thought to obstruct GABA uptake in the brain, making up for the possible muscle relaxant and anti-anxiety properties of this amazing active cannabinoid. The antidepressant traits of CBG are attributed to CBG’s ability to block serotonin receptors.


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Video by: מן קנאביס – What is CBG
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What are the Health Benefits of CBG

Before listing the huge potential health benefits of CBG, it is crucial to highlight that the beneficial therapeutic properties of CBG are known to work best when consuming whole cannabis plant-based products.

Whether it comes to smoking or vaping cannabis flowers, or taking advantage of weed tinctures, weed honey, cannamilk, or just about any possible form of cannabis consumption, marijuana enthusiasts should keep in mind that nothing can outperform ingesting as many of the active compounds found in the cannabis plant as possible, as to give way to the synergistic effect of the green medication (“the entourage effect”) to take place through the unique action of cannabis’ active compounds on your body’s endocannabinoid system.

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Video by: Healer – Your Endocannabinoid System Explained
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As shared in an explicit 2019 study published as part of the Cannabis Genomics, Breeding, and Production research topic, after examining the effects of cannabis treatment on human breast cancer cell lines, experts discovered that cannabis extract treatment that included the presence of small concentrations of CBG alongside THCA “demonstrated superiority” to the treatment with pure THC in its isolated form that lacks the full spectrum benefits of whole cannabis plant medicinals.

Pain

Lab tests suggest that CBG may possess a higher efficacy when it comes to alleviating pain (and especially when it comes to alleviating neuropathic pain) than CBD does. CBG’s effect on relieving muscle tension is especially well-pronounced.

Anxiety

Because of the research data showing that CBG works as a GABA uptake inhibitor, it is believed to be helpful for reducing anxiety.

Depression

As CBG helps to block serotonin while further boosting levels of anandamide, CBG is believed to be a potentially useful antidepressant agent.

Glaucoma

Being a crucial player in the “entourage effect” where all of the active compounds found in the cannabis plant are believed to play a unique, vital role, CBG is an important part of cannabinoids’ synergistic action on reducing intraocular pressure. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1772142/)

Digestive Conditions and Inflammation

A 2013 study confirmed that CBG has helped in lowering bowel inflammation in mice. In fact, the effects of CBG on lowering bowel inflammation in mice was so significant that the researches insisted on further clinical CBG experimentation involving human patients with inflammatory bowel disease-related issues.

Not the least, CBG experimental studies have shown promising results in Cannabigerol’s ability to improve Crohn’s disease- and ulcerative colitis-related inflammation and digestive conditions.

Skin Conditions

As CBG has demonstrated to induce production of the body’s natural skin moisturizers, it is said to possess a huge potential for treating dry skin syndromes, as well as other skin conditions related to insufficient levels of natural skin moisturizers.

Neuroprotection

Although further research is needed, studies on rats have shown that Cannabigerol has essential neuroprotective properties, making it a potential treatment for Huntington’s disease, among other neurodegenerative disorders.

Antibacterial

Despite not being able to determine the exact mechanisms through which active cannabinoids can help to substitute traditional antibiotics, especially with a mind to the ongoing issues regarding antibiotic resistance, studies have shown that CBG, CBC, THC, CBN, and CBN all possess promising properties in terms of their antibacterial effects.

Bladder Disorders

A study focused on the investigation of anectodal claims on the usefulness of cannabis for the treatment of bladder dysfunctions found that CBG, along with other active cannabinoids, decreases bladder contraction in both mice’, as well as the human bladder.

Appetite Boost

Researchers investigating the appetite stimulation properties of THC found out that even in the absence of THC, CBG may help to significantly boost appetite.

Anti-Cancer

Similar to other active cannabinoids, CBG has also been discovered to help inhibit the formation of new cancer cells. The carcinogenesis inhibiting properties of CBG is yet to be researched outside laboratories, but even with limited evidence on that matter, the results seem more than just promising, according to researchers.

CBG (Cannabigerol): The Takeaway

As CBGA, (the precursor to CBG), is known as the parent of many major active cannabinoids, it is only fair to think of Cannabigerol as a mighty source of a quite great deal of the healing power that is packed inside the cannabis plant.

So far, sufficient research on the benefits of CBG is still lacking but that’s major because of the regulations that have been blocking further investigations on that matter. Also, in order for a study to be scientifically valid, it needs to be executed over a large period of time, involving a large group of people, both of which used to be impossible due to the ban on marijuana. However, even though mostly limited to animal studies and tons of anecdotal evidence, it seems crystal clear that the cannabis plant holds ancient secrets to promoting people’s well-being in every meaningful way.

Scientists are still learning about the many effects of CBG, making it a powerful cannabinoid in its own, unique right. Fortunately, further ongoing studies will help to reveal more about the exact mechanisms through which CBG (Cannabigerol) works, as well as what these mechanisms can provide for both recreational and medical marijuana users around the globe.

To finish this article in a way that is as useful as possible to all of our bud buddies out there, we have compiled a shortlist of some of the cannabis strains that possess higher levels of CBG than others. For those of you who happen to grow their cannabis plants from seeds, we want to wish you a beautiful journey discovering the superpowers of the cannabis plant, because there is no better way to become one with the healing mind and body properties of marijuana consumption than getting to know these enchanting creatures through the first-hand experience, especially when doing so puts you 100% in charge of being perfectly well-aware and informed on exactly what gets into your body after consuming your proudly homegrown green medication.

1. Afghani

The beloved, all-time favorite representative of pure Indica genetics is known to contain an estimated of 0.172% CBG.

2. AC/DC

The Sativa-dominant beast AC/DC is known to top about 0.142% CBG.

3. AK/47

AK/47 is not merely a mighty weapon against pain and fatigue, but also a suitable source of CBG, thanks to the estimated of 0.166% CBG content.

4. Berry White

Berry White, the hybrid strain that has become a top favorite choice for both recreational and medical marijuana users alike, is known to possess an average of 0.132% CBG.

5. Green Crack

The anti-depression warrior Green Crack strain can provide you roughly 0.131% CBG.

If these levels of CBG seem quite small, do mind that many strains contain as little as 0% CBG, most gravitating towards some average 0.040%, for instance, the legendary Blueberry strain contains about 0.019% CBG, so anything exceeding 0.100% is actually considered to be a quite above the average normCannabigerolcontent! Wishing you a beautiful and meaningful journey through discovering the ancient secrets of Cannabigerol and the cannabis plant, helping you grow in every aspect of life.